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KMID : 1134820130420060892
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 6 p.892 ~ p.897
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Acute Toxicity of Crude Anti-fungal Compounds Produced by Lactobacillus plantarum AF1
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Son Hee-Kyoung
Lee Myong-Ryeol
Chang Hae-Choon
Lee Jae-Joon
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Abstract
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We investigated the acute toxicity from a single dose of crude anti-fungal compounds produced by Lactobacillus plantarum AF1, a lactic acid bacterium isolated from kimchi, on ICR male and female mice in vivo. The test article was orally administered once to both sexes of mice. The mortality rate, clinical findings, autopsy findings, and body weight changes were monitored daily for 14 days. In the oral acute toxicity test, male and female mice were gavaged with four doses (5, 50, 300 or 2,000 mg/kg) of the crude anti-fungal compounds. The oral LD50 of the crude anti-fungal compounds was higher than 2,000 mg/kg. No significant changes in general conditions, body weights, clinical signs, or appearance of gross lesions were observed. In conclusion, our results suggest a low toxicity and no-adverse-effects from crude anti-fungal compounds produced by Lactobacillus plantarum AF1 up to 2,000 mg/kg via the oral route.
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KEYWORD
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Lactobacillus plantarum AF1, acute toxicity, crude antifungal compound, mice
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